Sources of common compounds: 930-62-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dimethylimidazole, and friends who are interested can also refer to it.

Reference of 930-62-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 930-62-1 name is 2,4-Dimethylimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 2-imidazol-1 -yl-ethylamine derivatives by lambda/-alkylation of disubstituted imidazoles [general procedure (GP9)]Sodium hydroxide (180 mmol; powder) and tetrabutylammonium hydrogensulfate (1.80 mmol) were successively added to a solution of the respective imidazole derivative (45.00 mmol) in MeCN (100 ml). After 30 min., 2-chloroethylamine hydrochloride (54.00 mmol) was added and the reaction mixture was stirred for 24h at reflux. The obtained suspension was filtered and the filtrate was concentrated in vacuo to give a crude oil which was used without further purification.2-(2,4-dimethyl-imidazol-1-yl)-ethylamine Prepared by lambda/-alkylation of 2, 4-dimethyl-1 /-/-imidazole according to the previously described general procedure (GP9).1H-NMR (CDCI3; 300 MHz): delta = 6.50 (s; 1 H), 3.76 (t, J = 6.2 Hz, 2H), 2.91 (t, J = 6.2 Hz, 2H), 2.28 (s, 3H), 2.09 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dimethylimidazole, and friends who are interested can also refer to it.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/78291; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem