Synthetic Route of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(3-bromophenyl)(9,9-dimethyl-9H-xanthen-4-yl)diphenylsilane (2, 300 mg, 0.55 mmol), 5H-benzo [d]benzo[4,5]imidazo[1,2-a]imidazole (3, 125 mg, 0.603 mg),cBRIDP (19.3 mg. 0.055 mmol) and tBuONa (132 mg, 1.37mmol) were dissolved in xylene (5 mL). The mixture wasdegassed by bubbling nitrogen through for 15 min. Alkylpalladiumchloride dimer (6 mg, 0.016 mmol) was added,and the mixture was again degassed by bubbling nitrogenthrough for another 15 min before being heated to 120 C.for 2 h. The reaction was quenched with water. The organicphase was separated and the aqueous phase was extractedwith dichloromethane. The combined organics was dried onMgS04 , filtered, and concentrated in vacuo. The crudeproduct was purified using reverse phase chromatography(20:80 to 70:30 THF:water, 1CV, 70:30 to 100:0 THF:water,10 CV, then THF). The crude product was then re-purifiedusing reverse phase chromatography (20:80 to 40:60 THF:water, 1 CV, 40:60 to 70:30 THF:water, 10 CV, then 70:30THF:water). The product was purified using normal phaseflash colunm chromatography (silica, 1:99 to 100:0 dichloromethane:heptane ). It was retained on the silica before 1:1THF:dichloromethane was used. This material was purifiedagain by normal phase chromatography (silica, 50:50 to100:0 dichloromethane:heptane) to afford Compound A aswhite solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Universal Display Corporation; Wolohan, Peter; Feldman, Jerald; (128 pag.)US2018/287079; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem