3584-66-5, name is 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H4Cl4N2
To a suspension [OF 5-CHLORO-2-TRICHLOROMETHYL-1H-BENZOIMIDAZOLE] (100 mg, 0.37 mmol) in acetonitrile (4 mL) was added N-methylpiperazine (0.04 mL, 0.4 [MMOL).] The mixture was stirred for 10 min then ammonium acetate (29 mg, 0.38 [MMOL)] was added. After 18 h the reaction mixture was diluted with satd aq [NAHCO3] (10 mL), and then extracted with [DICHLOROMETHANE] [(3 X 10] mL). The combined extracts were dried [(NA2SO4)] and then concentrated under reduced pressure. The crude product was purified on silica gel (10 g; 0-10% methanol (2 M NH3)/dichloromethane) to afford 23 mg (22%) of the title compound. MS [(ESI)] : mass calculated for [C13H16N40,] 277.11 ; [M/Z] found, 278.2 [M+H] [+. 1H] NMR (400 MHz, CD30D) : 7.79-7. 74 [(M,] 2H), 7.45 (dd, [J =] 8.6, 2.0 Hz, [1H),] 4.23-4. 17 (m, 4H), 3.63-3. 58 (m, 4H), 3.01 (s, 3H).
The synthetic route of 3584-66-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/22060; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem