Some common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 641571-13-3
PAL-resin 4-methyl-3-nitro-aniline (5g, 5mmol), bis (2-oxo-3-oxazolidinyl) phosphinic chloride (5.09g, 20mmol), DIEA (3. 5mL, 20mmol), and 3- (4-methyl-imidazol-1-yl)-5- trifluoromethyl-benzoic acid (2. 71g, 10.0mmol) are mixed in DMF (50mL) with shaking at room temperature for 18 hours. The resultant mixture is filtered and the resin is washed with DMF (3x50mL), CH2Cl2 (3x50mL), MeOH (3x50mL), and dried under vacuum. lOmgs of this resin is treated with TFA/CH2Cl2/H20 (45/50/5) (20011L) for 30 minutes. LC-MS shows only one peak: observed MS (M + H+) is 405.1 ; calculated MS (M + H+) is 405.11.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-13-3, its application will become more common.
Reference:
Patent; IRM LLC; WO2005/39486; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem