Related Products of 1262035-61-9, A common heterocyclic compound, 1262035-61-9, name is 5-Bromo-1-cyclopropyl-1H-imidazole, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 4-[(3-Cyclopropyl-3H-imidazol-4-yl)-hydroxy-methyl]-benzonitrile In a 10 mL two-necked flask, 5-bromo-l-cyclopropyl-lH-imidazole (intermediate lc’, 107 mg, 572 muiotaetaomicron, Eq: 1.00) was combined with DCM (3 ml) to give a colorless solution. Isopropyl magnesium chloride, lithium chloride complex (484 mu, 629 muiotaetaomicron, Eq: 1.1) was added within 2min (white precipitate). After stirring for 80min., the reaction flask was cooled to 0C, and a solution of 4-formylbenzonitrile (90.0 mg, 686 muiotaetaomicron, Eq: 1.2) in DCM (2 ml) was added dropwise. The reaction was allowed to proceed at rt for 2 h when TLC showed that the reaction was complete. Work up: The reaction mixture was quenched with 3ml sat. NH4C1, then poured into 6ml sat. NaHC03 and extracted with DCM (2X 25ml). The organic layers were washed with brine, combined, dried over Na2S04, and concentrated i. V. The crude material was purified by flash chromatography (silica gel, 20g, 2% to 10% MeOH in DCM) to yield 81 mg of the title compound as white foam. MS (ESI): 240.1 [M+H]+.
The synthetic route of 1262035-61-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KUHN, Bernd; MAERKI, Hans, P.; MAYWEG, Alexander, V.; MOHR, Peter; TAN, Xuefei; WO2013/120771; (2013); A1;,
Imidazole – Wikipedia,
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