Electric Literature of 104619-51-4,Some common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, molecular formula is C7H7N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6-(trifluoromethyl)oxazolo[4,5-c]pyridin-2-amine 5-amino-2-(trifluoromethyl)pyridine-4-ol (220 mg, 1.24 mmol) was dissolved in anhydrous THF (7 mL). Di(1H-imidazol-1-yl)methanimine was then dissolved into the solution. The reaction was stirred at 65 C. for 24 hours. After cooling the solution to room temperature, the solution was taken up in ethyl acetate and washed with deionized water, saturated NH4Cl, and saturated NaCl. The organic layer was dried over MgSO4, filtered, and concentrated down to the crude material. Excess CH2Cl2 was added to the crude solid, which precipitated out. The pure solid was filtered and dried under vacuum. Yield: 91%. 1H NMR (400 MHz, DMSO): 8.58 (s, 1H), 8.17 (s, 2H), 8.02 (s, 1H). [M+1]+=204.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Di(1H-imidazol-1-yl)methanimine, its application will become more common.
Reference:
Patent; Indiana University Research and Technology Corporation; The Brigham and Women’s Hospital, Inc.; Androphy, Elliot J.; Hodgetts, Kevin; Calder, Alyssa Nicole; (46 pag.)US2017/239225; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem