Adding a certain compound to certain chemical reactions, such as: 113775-47-6, name is Dexmedetomidine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113775-47-6, Safety of Dexmedetomidine
20 g (100 mmol) of 4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazole and 9 g (70 mmol) of L – (+) – tartaric acid were added to 80 ml of absolute ethanol,Heated to 65 stirring,After the reaction was dissolved to continue stirring for two hours,Then cooled to 10 C,Stir overnightAt this time a large number of white solid,Suction filtration,The filter cake was washed with absolute ethanol,Get dexmedetomidine tartrate 16.6g,Yield 47.3%The ee value is 99.24%.
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Reference:
Patent; Tsingtao Chenda Biological Technology Co., Ltd.; Lv Yanhua; (8 pag.)CN106588778; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem