Application of 95470-42-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95470-42-1 as follows.
After the addition of K2CO3(1.05 g, 7.63 mmol) thereto, a solution of 2-bromo-4-methyl-lH-imidazole-5-carboxylic acid ethyl ester (1.2 g, 5.08 mmol) in DMF (45 ml) was stirred at room temperature for 30 min and mixed with benzyl chloride (0.7 ml, 6.10 mmol). The reactants were induced to react therewith by elevating the temperature to 120¡ãC with stirring for 8 hrs. After the completion of reaction, the reaction mixture was cooled and added with water. Then, extraction with ethyl acetate was precedent to drying over MgSO4, followed by filtration and vacuum concentration. Through silica gel column chromatography (hexane : ethyl acetate = 8:1), the concentrate thus obtained was purified to the object compound as a white solid (1.06 g, 3.28 mmol, 65percent) .
According to the analysis of related databases, 95470-42-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY; WO2008/111794; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem