Related Products of 2466-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2466-76-4 name is 1-(1H-Imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The amine precursor 16 (100,7 mg, 0.240 mmol, 1 eq.) was dissolved in 1 ml of DMF, acetylimidazole (31.7 mg, 0.288 mmol, 1.2 eq) and DIPEA (0.090 ml, 0.48 mmol, 2 eq.) wereadded to the solution. After stirring the mixture for 48h at room temperature, the solvent was evaporated under reduced pressure to give the corresponding crude, which was purified by HPLC using a gradient of 5percent to 95percent v/v acetonitrile in 0.1percent aqueous solution of formic acid to yield the titled compound. Yield: 91 mg, 0.187 mmol (78percent). 1H NMR (400 MHz, CDCI3) 9.25 (1H, 5), 8.70 (1H, 5), 7.97 (1H, t, J=6.5 Hz), 7.15 (1H, d, J=7.5 Hz), 6.83-6.80 (2H, m),6.72 (1H, d, J=8.8 Hz), 4.92-4.88 (1H, m), 4.57 (1H, 5), 4.52-4.42 (2H, m), 4.26-4.14 (2H, m), 3.59 (1H, dd, J=2.9, 11.1 Hz), 2.53-2.45 (4H, m), 2.24-2.17 (1H, m), 1.85 (3H, 5), 0.83 (9H, 5); 13C NMR (101 MHz, ODd3) O 171.8, 171.2, 155.9, 150.7, 148.1, 132.8, 131.7, 131.0, 124.2, 120.6, 117.1, 70.3, 58.1, 57.7, 57.1, 39.8, 35.5, 34.8, 26.3, 22.6, 16.0. HRMS (ESI) m/z: [M+H] calculated for: C24H32N405S: 488.21; observed: 484.3.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-1-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF DUNDEE; CIULLI, Alessio; MANIACI, Chiara; HUGHES, Scott J.; TESTA, Andrea; (111 pag.)WO2018/189554; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem