These common heterocyclic compound, 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H8N2O
To a solution of N-[(2-chloropyridin-3-yl)methyl]-N-pyridin-3-ylpyridin-3-amine (59 mg, 020 mmol) and l-methyl-2-benzimidazolinone (45 mg, 0.30 mmol) in dry pyridine (1 mL) was added potassium acetate (51 mg, 0.512 mmol), cuprous chloride (11.6 mg, 0.117 mmol), and copper powder (31 mg, 0.487 mmol). This mixture was sealed and heated at 120 C for 4 days. The cooled reaction was diluted with NaHCtheta3 solution and the product extracted into methylene chloride. This solution was dried over anhydrous sodium sulfate, filtered, and the solvent evaporated This residue was subjected to chromatography on silica gel eluting with a 20-100% acetone/hexane gradient to give the title compound after trituration with diethyl ether as a white solid.IH-NMR (500 MHz, CDCl3): delta 8.54 (IH, d, J=3.7Hz), 8.36 (2H, v br s), 8.25 (2H, v br s), 7.95 (IH, d, J=7.3Hz), 7.33 -7.38 (3H, m), 7.27(1H, m), 7.18 -7.21 (2H, m) , 7.12 (IH, t, J=7.8Hz), 7.05-7.08 (2H, m), 5.36 (IH, v br s), 4.88 (IH, v br s), 3.47(3H, s). m/e (m+1): 409.2.
The synthetic route of 1-Methyl-1H-benzo[d]imidazol-2(3H)-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2007/89735; (2007); A2;,
Imidazole – Wikipedia,
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