Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16265-04-6, name is 2-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-1H-imidazole
4 g of 98percent sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 ¡ã C, slowly dropping from 1. 9g95percent fuming nitric acid (0. 03mol) and 5g 20percent fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 ¡ã C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3percent HPLC purity 99. 4percent, melting point 218. 6 ~ 219.5 ¡ã C.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Yancheng Institute Of Technology; Zhao, LingLing; Dai, Yong; Qi, gang; (5 pag.)CN103396369; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem