Reference of 6160-65-2,Some common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the protection of argon, the cross spore alkali (1.86 g, 4.0 mmol) for 100 ml dichloromethane dissolved, at room temperature by adding 10 ml triethylamine andN,N’ – Sulfur carbonyl diimidazole (1.3 g, 8.0 mmol), the reaction overnight at room temperature. The reaction solution is poured into 100 ml ice water, dichloromethane extraction, anhydrous sodium sulfate after drying the organic phase concentration, silica gel column chromatography separation, dichloromethane: methanol=20:1 (v/v) elute and get the 3′ -N- (1 – Imidazole sulfur on behalf of the carboxamido) cross spore alkali 1.9 g, yield 82%,
The synthetic route of 6160-65-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guizhou Chinese Academy Of Sciences Natural Result Chemical Emphasis Experiment Shi (Guizhou Medical University Natural Result Chemical Emphasis Experiment Shi); Wang Liping; Zhu Weiming; Li Mingpeng; Xu Yanchao; Zuo Mingxing; (25 pag.)CN109879888; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem