Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15965-31-8, name is 5-Chloro-1H-imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C3H3ClN2
To a vial charged with 3 -(5- bromo-6-methoxypyridin-2-yl)-4-(4-methoxybenzyl)-5-(7-methylbenzofuran-2-yl)-5 ,6- dthydro-4H-1,2,4-oxadiazine, fraction (II) Example 6B (100 mg, 0.19 mmol, 1.0 equiv.), 4- chloro-1H-imidazole (40.4 mg, 0.38 mmol, 2.0 equiv.), and K3P04 (81.2 mg, 0.38 mmol, 2.0 equiv.) under N2 atmosphere was added degassed 4:1 PhMe:dioxane solvent mixture (0.80 mL). To a second vial charged with Pd2(dba)3 (7.00 mg, 0.008 mmol, 4.0 mol%) and Me4-di- t-BuXPhos (CAS 857356-94-6, 7.40 mg, 0.02 mmol, 8.0 mol%) under N2 atmosphere was added degassed 4:1 PhMe:dioxane solvent mixture (0.40 mL). This mixture was stirred for 3minutes at 120 C to provide a dark red solution which was cooled to RT and transferred to the first vial. The reaction was degassed by bubbling with N2 for 5 minutes and then sealed. The reaction mixture was stirred at 120 C for 16 h. The reaction was cooled to RT and filtered through a pad of celite which was washed thoroughly with EtOAc. The filtrate was concentrated, and the residue was purified by normal phase chromatography on silica (0-5% MeOH / DCM) to afford the product (90.0 mg, 86%) as a white solid. LCMS (ES+) [M+Hj+: 544.2/546.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FORUM PHARMCEUTICALS INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (451 pag.)WO2016/201168; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem