In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40197-20-4 as follows. Application In Synthesis of 5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid
Preparation Example 1 N-[3-(dimethylamino)propyl]-N’-ethylcarbodiimide hydrochloride (1.2 g) was added to a mixture of 5-bromo-1H-benzimidazol-2-carboxylic acid (1.0 g), 1-[4-(trifluoromethyl)benzyl]piperazine (1.0 g), 1H-benzotriazol-1-ol (840 mg), and N,N-dimethylformamide (10 ml: hereinafter, abbreviated as DMF), followed by stirring at room temperature overnight. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, followed by stirring at room temperature for 1 hour, and the resulting solid was collected by filtration, followed by drying under reduced pressure. The obtained solid was dissolved in a mixture of chloroform (100 ml) and ethanol (1 ml) while heating to reflux. The mixture was cooled to room temperature and then hexane (100 ml) was added thereto. The resulting solid was collected by filtration, followed by drying under reduced pressure, thereby obtaining (5-bromo-1H-benzimidazol-2-yl){4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone (1.4 g) as a solid.
According to the analysis of related databases, 40197-20-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Astellas Pharma Inc.; NAGASHIMA, Takeyuki; (31 pag.)EP3231426; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem