Related Products of 71759-87-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
[0297] To a solution of 4-iodo-l -methyl- lH-imidazole (34.0 g, 163 mmol) in THF (300 mL) at -10 C was added isopropylmagnesium chloride (25.0 g, 244 mmol) dropwise under N2. The mixture was stirred for 1 h at this temperature, and then tributylchlorostannane (55.6 g, 171 mmol) was added drop-wise. The reaction was stirred at room temperature overnight under N2. The reaction mixture was diluted with saturated aqueous NH4Cl (400 mL) and extracted with EtOAc (200 mL x 3). The combined organic phases were washed with water (200 mL x 2) and brine (200 mL), dried over Na2S0, and concentrated to dryness, to afford the desired product (65.0 g, 100 %) as colourless oil, which was used in the next step directly. [0298] LC-MS (Agilent): Rt 2.84 min; m/z calculated for Ci6H32N2Sn [M+H] + 373.2, found 373.2
The synthetic route of 4-Iodo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EPIZYME, INC.; HARVEY, Darren Martin; CAMPBELL, John Emmerson; DUNCAN, Kenneth William; (246 pag.)WO2019/108824; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem