Synthetic Route of 23328-88-3, These common heterocyclic compound, 23328-88-3, name is 2-Bromo-4-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: 2-(2-bromo-4-methyl-1H-imidazol-1-yl)-6-methoxy-3-nitropyridine To a mixture of 2-chloro-3-nitro-6-methoxypyridine (9.43 g, 50 mmol) and 2-bromo-4-methylimidazole (9.66 g, 60 mmol) in 300 mL of DMF was added freshly powdered KOH (3.36 g, 60 mmol) at 0 C. The resulting mixture was stirred at RT for 4 h. Solvent was removed by rotavap and the residue was washed with water and extracted with ethyl acetate (3*). Standard work-up followed by column chromatography using 30-50% ethyl acetate in hexane as eluent provided the product (13.82 g, 88% yield). MS (ESI) 313.0 [M+H]+
Statistics shows that 2-Bromo-4-methyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 23328-88-3.
Reference:
Patent; WYETH; US2010/120762; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem