3304-70-9, name is Dimethyl 4,5-imidazoledicarboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Dimethyl 4,5-imidazoledicarboxylate
1H-Imidazole-4,5-dicarboxylic acid dimethyl ester (2 g, 10.87 mmol, 1 equiv. ) was dissolved in THF (55 mL, 0.2 M) and DMAP (1.46 g, 11.95 mmol, 1.1 equiv. ) before Di- tert-butyl dicarbonate (3.50 g, 16.29 mmol, 1.4 equiv. ) was added. The reaction was stirred for 16 hours before being quenched with saturated NH4Cl (30 mL) and extracted with ethyl acetate (2 x 30 mL) and the organic layer washed several times with water (4 x 30 mL), brine solution (50 mL). It was dried over Na2SO4, filtered and concentrated in vacuo. Imidazole-1,4,5-tricarboxylic acid 1-tert-butyl ester 4,5-dimethyl ester 252 (3.85 g, 100%, 10.87 mmol). 1H NMR (300 MHz) CDCl3 delta 8.02 (s, 1 H), 3.99 (s, 3 H), 3.92 (s, 3 H). MS: 306.8 (M+23). TLC Rf: 0.6 Hexanes/Ethyl acetate (1/1)
The synthetic route of 3304-70-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gilead Sciences, Inc.; WO2004/35576; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem