Application of 13750-62-4, These common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[1-BENZYL-2-METHYL-1H IMIDAZOLE] (50 mg, 0.3 mmol) and 3,4-dichlorobenzyl bromide (77 mg, 0.32 mmol) in 0.2 ml acetonitrile (a few drops of DMF were added for solubility) were stirred overnight at room temperature. The mixture was diluted with ether, the solid filtered, washed with ether and dried to give 112 mg of product. LC/MS (ES+) m/e 333 [[M+1]]
The synthetic route of 13750-62-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/101970; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem