Application of 1072-63-5,Some common heterocyclic compound, 1072-63-5, name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Allyl chloride (0.10 mol, 7.652 g) was added dropwise over a periodof 30 min to a round-bottomed flask containing 1-benzylimidazole(0.05 mol, 7.910 g) in 20mLAcN under continuous stirring. The mixturewas then stirred for about 1 h and subsequently refluxed at 70 C for24 h till a light brown liquid forms. Excess reactants and solvent wereremoved by rotary evaporation. The crude product was then diluted inan appropriate volume of water and washed three times with 15 mLethyl acetate in a separating funnel. Finally, excess water was removedby rotary evaporation and dried under vacuum at 60 C overnight
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Vinyl-1H-imidazole, its application will become more common.
Reference:
Article; Sidek, Nadiah; A. Manan, Ninie S.; Mohamad, Sharifah; Journal of Molecular Liquids; vol. 240; (2017); p. 794 – 802;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem