Synthetic Route of 870837-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
t-BuLi (0.188 ml_, 0.32 mmol, 1.7 M) was added dropwise to a solution of compound D6 ((S), R6 = H, R7 = Ph; 46 mg, 0.21 mmol) in THF (1.5 ml_) at -78 0C. The mixture was stirred for 45 minutes before compound D7 (R10 = 3-MeO- Phenyl, R9 = 4-(4-methylimidazol-1-yl)) was added in THF (1.0 ml_) in fast drops. The resulting mixture was stirred for 2 hours before it was diluted with EtOAc (50 ml_) and NH4CI solution (10 mL). The organic layer was washed with brine, dried over MgSO4, and concentrated to give the crude product which was purified by column chromatography eluting with EtOAc/hexanes to yield compound D8 ((S), R6 = H, R7 = Ph; R10 = 3-MeO-Phenyl, R9 = 4-(4-methylimidazol-1 -yl)).
The synthetic route of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2008/153793; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem