Adding a certain compound to certain chemical reactions, such as: 36947-68-9, name is 2-Isopropyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36947-68-9, Computed Properties of C6H10N2
A mixture of 2-bromo-N-tert-butyl-6-(4-chlorophenyl)-pyridine-4-carboxamide (intermediate 2) (91.9 mg, 250 mupiiotaomicron), commercially available 2-isopropyl-lH-imidazole (55.1 mg, 500 mupiiotaomicron) and potassium carbonate (69.1 mg, 500 mupiiotaomicron) in DMSO (1.5 ml) was purged with argon in an ultrasonic bath for 5 min, N,N-dimethylglycine (10.3 mg, 100 mupiiotaomicron) and copper(I)iodide (9.52 mg, 50 mupiiotaomicron) were added, the tube sealed and heated for 17h at 115C. The reaction mixture was diluted with water (10 ml), the precipitate collected by filtration and further purified by flash chromatography on silica gel [heptane/ethyl acetate (50-100%)] to yield the title compound (50 mg, 50%) as an off-white foam, MS (ISN) m/z = 397.3 [(M+H)+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Isopropyl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HOENER, Marius; WICHMANN, Juergen; (65 pag.)WO2017/9274; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem