These common heterocyclic compound, 37148-86-0, name is 4-(4-(Trifluoromethyl)phenyl)-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 37148-86-0
Sodium hydride (60% in oil) (32 mg) was added at 0 C. to a DMF (6.7 mL) solution of Reference Example 2 (0.17 g), and the mixture was stirred at 0 C. for 30 minutes. 2-Fluoro-4- (trifluoromethyl) benzonitrile (0.13 g) was added to the reaction solution at 0 C., and the mixture was stirred at room temperature for 3 hours. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with a saturated saline solution and dried over sodium sulfate. After evaporation of the solvent of the organic layer after drying under reduced pressure, the obtained residue was purified by silica gel chromatography (elution solvent; hexane: ethyl acetate) to obtain Reference Example 5 (0.18 g).
The synthetic route of 4-(4-(Trifluoromethyl)phenyl)-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; ISOBE, YOSHIAKI; BAN, HITOSHI; SAITO, YASUHIRO; WATANABE, HITOSHI; (44 pag.)JP2018/135270; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem