Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-56-4, name is 2-Bromo-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 16681-56-4
Example 242 Trans-4-(4-(imidazol-2-yl)-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide Trans-N-((R)-1-(4-fluorophenyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonamido)cyclohexanecaboxamide (Intermediate 64, 0.206 mmol), Pd(dppf)Cl2.DCM (19 mg, 0.023 mmol), 2M Na2CO3 (0.57 ml, 1.14 mmol) and 2-bromo-imidazole (17 mg, 0.114 mmol) dissolved in DMF (2 ml) under N2, and the mixture was microwaved at 160 C. for 20 min., after which LCMS indicated that the reaction was complete. The mixture was diluted with DCM and MeOH and filtered through a syringe filter. The filtrate was then passed through a 40+S biotage column with an isocratic gradient of 10% MeOH in EtOAc and the product fractions were combined and concentrated. Crude product was repurified via reverse phase chromatography on prep-HPLC (150 mm, C8 luna, 15-20 min run, 10%-100% MeCN in water containing 0.1% TFA) and the product containing fractions were lyophilized to yield the title compound as a white solid (4.2 mg, 3%). MS MH+ 471.1
The synthetic route of 16681-56-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BARNES, David; BEBERNITZ, Gregory Raymond; COHEN, Scott Louis; DAMON, Robert Edson; DAY, Robert Francis; JAIN, Monish; KARKI, Rajeshri Ganesh; KIRMAN, Louise Clare; PATEL, Tajesh Jayprakash; RAYMER, Brian Kenneth; SCHUSTER, Herbert Franz; ZHANG, Wei; US2011/136735; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem