288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1H-Imidazole
Synthesis of 1-benzylimidazole 9 illustrated by step (a) of FIG. 3. (0085) According to the selected experimental protocol, 44 g of imidazole (0.65 mol.), 100 g of benzyl chloride (0.78 mol.), and 60 g of KOH (1.07 mol.) in 700 ml of THF are placed in a 1-liter balloon flask. The reaction mixture is brought to reflux for 120 h, then cooled at ambient temperature. The organic phase is filtered and the solvent is evaporated under reduced pressure. The obtained solid product is dissolved in 500 ml of CH2Cl2, then washed with water (3¡Á100 ml). The organic phase is dried on Na2SO4, filtered, then evaporated under reduced pressure. The collected solid is recristallized in toluene to yield 67 g of desired product.
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Peugeot Citroen Automobiles SA; CNRS (Centre National de la Recherche Scientifique); Glipa, Xavier; Ameduri, Bruno; Delon, Louis; Jones, Deborah; Roziere, Jacques; Frutsaert, Guillaume; US8859160; (2014); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem