Adding a certain compound to certain chemical reactions, such as: 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-59-7, HPLC of Formula: C4H5BrN2
Similarly, compound f1 (6.05 g, 37.6 mmol)Dissolved in tetrahydrofuran (140 mL),Adding hexane solvent and dropping at -78 CAfter 2.5 M n-butyllithium (18 mL, 45.1 mmol),Stir for 1 hour.Then slowly add trimethyl borate (13 mL, 56.4 mmol)After that, stir for 2 hours.Then add 2M hydrochloric acid to neutralize,The product was extracted with ethyl acetate and water.Recrystallization from dichloromethane and hexane gave compound g1 (3.56 g, 77%).Weighed compound g1 (3.16 g, 25.1 mmol),Compound e1 (6.23 g, 25.1 mmol),Tetrakistriphenylphosphine palladium (11g, 10mmol)And potassium carbonate (8.42 g, 60.9 mmol),The weighed reactant was dissolved in toluene (1 L) / EtOH (200 mL) / distilled water (200 mL)The solvent was heated at 90 C for 2 hours.After the reaction is completed, the pressure is concentrated,Extract with ethyl acetate and concentrate.Column chromatography gave Intermediate A1 (4.07 g, 65%).
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Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Han Chunxue; Cai Hui; (33 pag.)CN108676034; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem