The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.
Reference of 641571-11-1,Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1; [240] Preparation of N-r3-f4-methylimidazol- l-ylV5-trifluoromethyl-phenyll-4-(4-pyridin-3-yl-Pyrimidin-2-ylaminos)-benzamide; EPO [241] 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid prepared in Preparation 19(242mg, 0.83mmol) and 3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenylamine prepared in Preparation 30 (200mg, 0.83mmol), N,N-dimethyl formamide (10ml), and diethylcyano phosphate ( 0.245ml, 1.658mmol) were added to a reaction vessel, and cooled to 100C. Triethylamine (0.231ml, 1.658mmol) was added thereto. After 30 min, the mixture was mixed at 600C for 15 hr. The mixture was cooled to RT, and an organic layer was obtained with the solution of ethyl acetate and sodium bi carbonate, concentrated under vacuum, and subjected to column chromatography (5: 1/CHC1 :MeOH) to give the titled compound as pale yellow solid.[242] 1H-NMR (DMSO-d , delta)= 2.20 (s,3H), 7.39 (s,lH), 7.56 (d,2H), 8.03 (m,5H), 8.17(s,lH), 8.21 (d,lH), 8.32 (s,lH), 8.49 (d,2H), 8.63 (d,lH), 8.72 (d,lH), 9.36 (s,lH), 10.15 (s, IH); 10.48 (s,lH)
The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IL-YANG PHARM. CO., LTD.; WO2007/18325; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem