Application of 14813-85-5,Some common heterocyclic compound, 14813-85-5, name is 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C13H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-phenyl-1,3-dihydro-benzimidazole-2-one, and 52g (250 mmol), in the first and K2CO3 of 38g (275 mmol), is introduced into the DMF of 100ml. After 1 hour at room temperature, it is added dropwise a solution of 2-bromobenzyl bromide 62g in DMF in 500 ml (250 mmol). The reaction mixture was then stirred for 25 hours at room temperature. After this time, the reaction mixture was poured onto ice, and extracted three times with dichloromethane. The combined organic phases are dried over Na2SO4, and evaporated. The residue was extracted with hot toluene, recrystallized from toluene / n-heptane. The yield is 65g (70%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Phenyl-1H-benzo[d]imidazol-2(3H)-one, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; STOESSEL, PHILIPP; PARHAM, AMIR HOSSAIN; PFLUMM, CHRISTOF; JATSCH, ANJA; EBERLE, THOMAS; KROEBER, JONAS VALENTIN; (86 pag.)JP2016/500675; (2016); A;,
Imidazole – Wikipedia,
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