Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-50-2, name is Imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 3034-50-2
First, 4-imidazole formaldehyde (1a, 960 mg, 10 mmol) was added to the reaction flask.Place in ice water bath. After 10min,Add triethylamine (TEA) (278 mul, 2.0 mmol) to the reaction flask,The mixture was stirred in an ice-water bath for 5 min.Di-tert-butyl dicarbonate (2.4 g, 1.0 mmol) was then added to the reaction flask.The reaction was moved to room temperature and reacted overnight. After the reaction was detected by TLC, the solvent was spin-dried.Alumina column chromatography (PE: EA = 2: 1) gave Intermediate 1b.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Xihua University; Wang Zhouyu; Qian Shan; Yang Lingling; Li Ling; Xu Wei; Yang Huan; Liu Siyan; Yao Hao; Yan Jie; Li Chao; (23 pag.)CN110294714; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem