Related Products of 111851-98-0, These common heterocyclic compound, 111851-98-0, name is 1-Ethyl-1H-imidazole-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00453] (¡ê)-3-(l-ethyl-lH-imidazol-2-yl)-l-(thiazol-2-yl)prop-2-en-l-one was prepared from l-(4-methylthiazol-2-yl)-2-(triphenyl- 5-phosphanylidene)ethan-l-one (1.0 equiv.) and 1 -ethyl- lH-imidazole-2-carbaldehyde5 via Wittig reaction (24 h) in 56 % isolated yield, using synthetic procedures described for the preparation of the analog SW209415. H NMR (400 MHz, CDCI3) delta 8.26 (d, / = 15.4 Hz, 1H), 8.03 (d, / = 3.0 Hz, 1H), 7.82 (d, / = 15.4 Hz, 1H), 7.67 (d, 7 = 3.0 Hz, 1H), 7.22 (s, 1H), 7.07 (d, 7 = 1.2 Hz, 1H), 4.15 (q, 7 = 7.4 Hz, 2H), 1.45 t, / = 7.3 Hz, 3H). ESI-MS (m/z): 234.1 [M+H]+.
Statistics shows that 1-Ethyl-1H-imidazole-2-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 111851-98-0.
Reference:
Patent; CASE WESTERN RESERVE UNIVERSITY; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; MARKOWITZ, Sanford D.; READY, Joseph; ZHANG, Yongyou; ANTCZAK, Monika; WILLSON, James K.V.; POSNER, Bruce A.; GREENLEE, William; (254 pag.)WO2016/168472; (2016); A1;,
Imidazole – Wikipedia,
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