Adding a certain compound to certain chemical reactions, such as: 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14741-71-0, category: imidazoles-derivatives
General procedure: To a solution of compound 3 (2.04 g, 0.01 mol) in ethanol (30 mL) containing piperidine (0.50 mL) either benzaldehyde (1.06 g, 0.01 mol) or 4-methoxy benzaldehyde (1.31 g, 0.01 mol) or 4-chlorobenzaldehyde (1.34 g, 0.01 mol) was added. The reaction mixture, in each case, was heated under reflux for 3 h then poured onto ice/water mixture containing few drops of hydrochloric acid and the formed solid product was collected by filtration. Ethyl 2-(1H-benzo[d]imidazol-2-yl)-3-phenylacrylate (7a). Gray crystals from ethanol; yield:2.45 g (77%); m.p. > 300 oC. IR, : 3478-3329 (NH), 3057 (CH aromatic), 2962, 2873 (CH3,CH2), 1688 (C=O), 1646 (C=N), 1630 (C=C). 1H-NMR: : 1.14 (t, 3H, J = 7.66 Hz, CH3), 4.21(q, 2H, J = 7.66 Hz, CH2), 6.24 (s, 1H, CH=C), 7.29-7.38 (m, 9H, C6H5, C6H4), 8.26 (s, 1H, NH,D2O exchangeable). 13C NMR (DMSO): 16.3 (ester CH3), 52.5 (ester CH2), 89.3, 90.2 (CH=C),120.6, 122.1, 123.2, 123.9, 124.1, 124.6, 125.8, 126.2, 127.8, 128.2, (C6H5, C6H4), 164.8 (CO),172.6 (C=N); Anal. calcd for C18H16N2O2: C, 73.95; H, 5.52; N, 9.58%. Found: C, 72.73; H,5.49; N, 9.37%. MS: m/z: (%) 292 (M+, 64%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem