Synthetic Route of 496-46-8,Some common heterocyclic compound, 496-46-8, name is Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione, molecular formula is C4H6N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 6; PREPARATION OF A CUCURBITURIL TRIMER; A CB trimer, according to the present invention, can be prepared according to two converging pathways, as is detailed hereinabove (Example 5) and is further presented in Figure 6. In general, one route of synthesizing a CB trimer involves formation of a derivatized CB monomer prior to the trimerization step, and another route involves formation of an assembling unit on which three CB moieties are formed in a consecutive step. As an exemplary starting material for both routes, a glycoluril derivatized by a fused pyrrolidine ring (Figure 6, Compound 19) is prepared, either by reacting diethyl iminodiacetate (Figure 6, Compound 15) with 4-morpholin-4-yl-furan-3-one (Figure 6, Compound 16), or by reacting dimethylester-glycoluril (Figure 6, Compound 17) and 2,5-dione-pyrollidono-glycoluril (Figure 6, Compound 18). Compound 19 is reacted with glycoluril, Compound 2, in a 1: 5 ratio with formaldehyde, in the presence of concentrated sulfuric acid, to thereby form the derivatized cucurbituril pyrrolidino-CB [6] (Figure 6, Compound 20). Compound 20 is thereafter converted to the cyanoamine and the latter is reacted so as to form a CB trimer (as presented in Figure 6, Compound 22) having a triazine ring as the assembling unit. Alternatively, Compound 19 is first converted to the cyanoimine, which is thereafter reacted so as to form the triazine ring at the center of trimerization. The resulting 1, 3,5-tri (2,5-dione-pyrollidono-glycoluril)-triazine (Figure 6, Compound 21) is reacted with glycoluril, Compound 2, in a 1: 15 ratio and with formaldehyde, in the presence of concentrated sulfuric acid, to thereby form a cucurbituril trimer (Figure 6, Compound 22) having a triazine ring as the assembling unit.
The synthetic route of 496-46-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.; WO2005/23816; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem