Adding a certain compound to certain chemical reactions, such as: 5465-29-2, name is 2-Propylbenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5465-29-2, COA of Formula: C10H12N2
General procedure: To a solution of [DodecIm][HSO4]* (5.00 mol%, 16.7 mg) in 95% EtOH (5.00 mL) was added aldehyde (2) (1.00 mmol) and o-phenylenediamine (1a) (1.20 mmol, 129.8 mg) or 2-amino-4-fluoroaniline (1c) (1.20 mmol, 151.2 mg) at room temperature respectively. The reaction mixture was stirred at room temperature for 12 h and then ethanol solvent was removed by rotary evaporator. The crude residue was diluted with water (5.00 mL)No. and extracted with ethyl acetate (3 * 5 mL). The combine organic layer was concentrated using rotary evaporator. Then crude residue was dissolved in acetonitrile (5.00 mL), followed by adding KOH (2.00 mmol, 112 mg) and alkyl halide (2.00 mmol) at room temperature respectively. The reaction mixture was stirred at room temperature for 0.5-24 h. After the reaction completed, the reaction mixture was neutralized with sat. NH4Cl and extracted with ethyl acetate (3 * 15 mL). The combine organic layer was dried over sodium sulfate anhydrous and concentrated using rotary evaporator. The crude product was purified by column chromatography (SiO2, 10-50% ethyl acetate/n-hexane as eluent depend on each derivatives) to give the desired products 5a-5z. *Recycling experiment. After extraction, the water layerNo. was removed to give the catalyst III. Recovered catalyst III was reused directly by adding EtOH and substrates in the next run without purification. Spectral data of compounds 5b [24], 5c [24], 5l [3c], 5o [26], and 5q [25], were previously described in the literature.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Propylbenzimidazole, and friends who are interested can also refer to it.
Reference:
Article; Senapak, Warapong; Saeeng, Rungnapha; Jaratjaroonphong, Jaray; Promarak, Vinich; Sirion, Uthaiwan; Tetrahedron; vol. 75; 26; (2019); p. 3543 – 3552;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem