Related Products of 221289-88-9,Some common heterocyclic compound, 221289-88-9, name is 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile, molecular formula is C8H5N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile (XVTI, 1.19 g, 7.48 mmol, 1 equiv) in acetonitrile (5 mL) was added phosphorus(v) oxy chloride (1.398 mL, 14.95 mmol). The reaction was stirred at 1 10 C for 16 hours, then cooled to room temperature. It was diluted with acetonitrile and then slowly added to a cold, rapidly -stirring beaker of saturated aqueous sodium bicarbonate (50 mL). The mixture was extracted with ethyl acetate; which was dried over anhydrous magnesium sulfate, filtered, and concentrated to provide 2~chloro-1H-benzo d]imidazole~6-carbonitrile as a tan powder. (ESI, pos. ion) m/z: 178.2 [M+i]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile, its application will become more common.
Reference:
Patent; AMGEN INC.; BARTBERGER, Michael D.; CHAKKA, Nagasree; GAO, Hua; GUZMAN-PEREZ, Angel; HORNE, Daniel B.; HUA, Zihao; KIEFFER, Madeleine; LIN, Daniel C. H.; MILGRAM, Benjamin Charles; PANTELEEV, Jane; SCHENKEL, Laurie; STELLWAGEN, John; WEISS, Matthew; WHITE, Ryan D.; ZHAO, Wei; (345 pag.)WO2019/79578; (2019); A1;,
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