In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54624-57-6, name is 2-Bromobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives
2-bromo-1 H-benzo[d]imidazole (177 mg, 0.9 mmol), bispinacolato diboron (250 mg, 0.99 mmol) and KOAc (265 mg, 2.7 mmol) were dissolved in dioxane (9 ml). After purging with N2, Pd(dppf)CI2 (37 mg, 0.045 mmol) was added. After stirring overnight at reflux temperature the reaction was cooled to room temperature the reaction mixture was diluted with some ethyl acetate (20 ml). The mixture was filtrated through a pad of celite and the solvent was evaporated under reduced pressure to give 2-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H- benzofdlimidazole as a black oil. The crude product was used in the next step without further purification
The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha; WO2013/41457; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem