Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111851-98-0, name is 1-Ethyl-1H-imidazole-2-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Ethyl-1H-imidazole-2-carbaldehyde
(Reference Example 23) Synthesis of (E)-methyl 3-(1-ethyl-1H-imidazol-2-yl)acrylate: Methyl (triphenylphosphoranylidene)acetate (3.15 g, 9.42 mmol) was added to a solution of 1-ethyl-1H-imidazole-2-carbaldehyde (1.17 g, 9.42 mmol) in dichloromethane (28.3 mL) at room temperature. The reaction liquid was stirred for 16 hours and concentrated under reduced pressure. The residue was washed with a mixed solvent of hexane/dichloromethane = 20/1 and the washing solution was concentrated. The residue was purified by flash column chromatography (silica gel, hexane/ethyl acetate) to obtain (E)-methyl 3-(1-ethyl-1H-imidazol-2-yl)acrylate (0.670 g, 3.72 mmol, 39%) as a white solid. 1H-NMR (400 MHz, CDCl3) delta: 1.45 (3H, t, J=7.6 Hz), 3.81(3H, s), 4.10 (2H, dd, J=7.6, 14.8 Hz), 6.85 (1H, d, J=15.2 Hz), 7.03 (1H, brs), 7.17 (1H, brs), 7.52 (1H, d, J=15.2 Hz). ESI-MS: m/z= 181 (M+H)+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 111851-98-0.
Reference:
Patent; Toray Industries, Inc.; ARAI Tadamasa; MORITA Yasuhiro; UDAGAWA Shuji; ISEKI Katsuhiko; IZUMIMOTO Naoki; (95 pag.)EP3263565; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem