Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33468-67-6, name is 2-Methyl-4-(trifluoromethyl)-1H-imidazole, A new synthetic method of this compound is introduced below., Safety of 2-Methyl-4-(trifluoromethyl)-1H-imidazole
Compound 218.1. 5-Iodo-2-methyl-4-(trifluoromethyl)-lH-imidazole. Into a 50- mL round-bottom flask, was placed a solution of 2-methyl-4-(trifluoromethyl)-lH-imidazole (compound 16.2, 1.72 g, 1 1.46 mmol) in CH3CN (25 mL). S (3.87 g, 17.20 mmol) was added to the reaction. The reaction mixture was stirred overnight at 85 C . The reaction mixture diluted with 50 mL of Iota0 and extracted with 3 x 30 mL of ethyl acetate . The combined organic layers were washed with 2 x 20 mL of a2S203(sat.) and 2 x 20 mL of brine , dried over anhydrous sodium sulfate and concentrated under reduced pressure. This resulted in 4.32 g (crude) of the title compound as a brown oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; 3-V BIOSCIENCES, INC.; HEUER, Timothy Sean; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2015/95767; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem