Related Products of 2849-93-6,Some common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 42-a (250.52 mg, 1.55 mmol, 1.03 eq) and HATU (1.14 g, 3.00 mmol, 2.00 eq) were dissolved in dichloromethane (20 mL), and stirred at room temperature for 15 min. Compound 7-a (235.82 mg, 1.50 mmol, 231.19 mL, 1.00 eq) and N,N-diisopropylethylamine (581.58 mg, 4.50 mmol, 785.92 mL, 3.00 eq) were then added, and stirred at room temperature for 18 hours. After the reaction was completed, the reaction solution was added with 150 mL of water, and extracted with dichloromethane (80 mL 3 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give a crude product. The crude product was subjected to column chromatography (petroleum ether : ethyl acetate = 1:0?5:2) to give the product of compound 42-b (288.00 mg, yield: 50%) as a yellow oil. LCMS m/z = 302.0 [M+H]+.
The synthetic route of 2849-93-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; HE, Haiying; WU, Songliang; LUO, Zhi; MOU, Jianfeng; GUO, Fengying; WANG, Chuan; LI, Guoqing; ZENG, Minggao; CHEN, Shuhui; (199 pag.)EP3456711; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem