In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3314-30-5 as follows. name: 1H-Benzo[d]imidazole-2-carbaldehyde
General procedure: The appropriate imidazolecarboxaldehyde derivative (10 mmol, 1 equiv.) was dissolved inmethanol. The amine (1 equiv.) in dry THF (5.0 mL), and activated 4 molecular sieves (2.00 g) wereadded. The reaction mixture was stirred at room temperature, under nitrogen for 12 hours. Then,sodium borohydride (1.2 equiv.) was added portionwise and the reaction was stirred at roomtemperature. After 3 hours water was added, and the mixture was stirred for 10 minutes. Molecular sieves were filtered off through a Celite pad. The filtrate was evaporated under reduced pressure.The residue was taken up with EtOAc and the organic layer was washed with 2N NaOH ( ¡Á 1), driedover sodium sulfate and concentrated in vacuo. The crude material was purified by columnchromatography using the indicated eluents
According to the analysis of related databases, 3314-30-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Galli, Ubaldina; Hysenlika, Rejdia; Meneghetti, Fiorella; Grosso, Erika Del; Pelliccia, Sveva; Novellino, Ettore; Giustiniano, Mariateresa; Tron, Gian Cesare; Molecules; vol. 24; 10; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem