Related Products of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 7; 2-Chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazole; To a suspension of sodium hydride (6.2 g, 245 MMOL) in DMF (275 mL) at 5 C was added 2-chlorobenzimidazole (37 G, 243 MMOL) via a solid-addition funnel over 30 min while maintaining the internal temperature of the mixture below 10 C. An additional 25 mL of DMF was added, and the ice bath was removed. After 2 h, 2-(TRIMETHYLSILYL) ETHOXYMETHYL CHLORIDE (SEM-CI) was added dropwise over 5 min. A white precipitate formed. The reaction mixture was stirred at room temperature for 18 h. To the mixture was added H20 (500 mL) and ethyl acetate (750 mL). The organic layer was washed with additional H20 (500 mL), dried (MGS04), and concentrated under reduced pressure, giving 65.8 g (96% yield) of the desired product as a clear golden oil, which solidified upon standing to give a beige solid. TLC (SI02, 5% ACETONE/CH2CI2) : Rf = 0.64. MS (ESI) : mass calculated for C13H19CIN2OSI, 282.10 ; m/z found, 283. 1. H NMR (400 MHz, CDC13) : 7.70 (d, J = 7.3, 1 H), 7.46 (d, J = 7.6, 1 H), 7.40-7. 25 (m, 2H), 3.58 (t, J = 7.9, 2H), 0.92 (t, J = 8.3, 2H), 0.04 (s, 9H)
The synthetic route of 4857-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12296; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem