Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7189-69-7, name is 1,1′-Sulfonyldiimidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 7189-69-7
A solution of n-butyllithium (2.50 M in hexanes, 340 muL, 0.86 mmol, 7.00 equiv) was added to astirred solution of hexamethyldisilazane (230 muL, 0.94 mmol, 7.70 equiv) in tetrahydrofuran (15mL) at 0 C. The resultant solution was warmed briefly to 23 C, then was cooled to 0 Cwhereupon a solution of 10 (50 mg, 0.12 mmol, 1 equiv) in tetrahydrofuran (5 mL) was added.The resultant mixture was stirred at 0 C for 30 min, then was cooled to -10 C whereuponN,N?-sulfuryldiimidazole (218 mg, 1.10 mmol, 9.00 equiv) was added. The reaction mixture waswarmed to 23 C and stirred at that temperature for 12 h. Excess N,N?-sulfuryldiimidazole wasquenched by the addition of methanol (5 mL), and the resultant mixture was concentrated. Theresidue was partitioned between saturated aqueous sodium bicarbonate solution (20 mL) anddichloromethane (20 mL). The layers were separated and the aqueous phase was extractedwith dichloromethane (3 ¡Á 25 mL). The combined organic layers were dried over anhydroussodium sulfate and the dried solution was concentrated. Purification of the residue by flashcolumn chromatography (20% ethyl acetate-hexanes) gave 28 (39 mg, 60%) as a colorless oil.
According to the analysis of related databases, 7189-69-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Fash, David M.; Peer, Cody J.; Li, Zhenwu; Talisman, Ian J.; Hayavi, Sima; Sulzmaier, Florian J.; Ramos, Joe W.; Sourbier, Carole; Neckers, Leonard; Figg, W. Douglas; Beutler, John A.; Chain, William J.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 11; (2016); p. 2641 – 2644;,
Imidazole – Wikipedia,
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