Related Products of 137049-00-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 137049-00-4 as follows.
5. SYNTHESIS OF (-)-2,4-DICHLORO-7V-(1 ‘-(l-METHYL-li-iMiDAzoL-4-YLSULFONYL)-2,3-DIHYDRO [INDENE- 1 ,4 ‘-PIPERIDINE] -2-YL)BENZAMIDE, 7B; [00235] To a solution of 6b (440 mg, 1.07 mmol) and DIPEA (384 muL, 2.14 mmol) in CH2Cl2 (12 mL) was added 1 -methyl- lH-imidazole-4-sulfonyl chloride (194 mg, 1.07 mmol). The reaction was stirred for 18 h. To the reaction mixture was added hexanes (4 mL) and isolated the white ppt by vacuum filtration to afford 7b (501 mg, 92%); Eta-nmr (400 MHz, CDCl3) delta 7.53 (s, IH), 7.46-7.44 (m, 2H), 7.37 (d, J= 2.0 Hz, IH), 7.30-7.18 (m, 5H), 6.06 (d, J= 10.0 Hz, IH), 4.91 (dd, J= 9.0, 6.0 Hz, IH), 3.88-3.72 (m, 5H), 3.43 (dd, J= 17.0, 6.0 Hz, IH), 3.14 (d, J = 12.5, 5.0 Hz, IH), 3.03 (td, J= 12.0, 3.0 Hz, IH), 2.81 (d, J= 16.0 Hz, IH), 2.27-2.21 (m, IH), 1.94 (d, J= 13.5 Hz, IH), 1.81-1.71 (m, 2H), 1.49 (dd, J= 35.0, 6.5 Hz, IH); m/z 519.1.
According to the analysis of related databases, 137049-00-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, Jeffrey, P.; WILLIAMS, Richard; JONES, Carrie, K.; SHEFFLER, Douglas, J.; WO2010/102003; (2010); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem