Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1122-28-7, name is 4,5-Dicyanoimidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4,5-Dicyanoimidazole
EXAMPLE 42 1-Propylphthalimido-4,5-dicyanoimidazole A solution of 4,5-dicyanoimidazole (24.8 g, 0.2 mol) in DMF (500 mL) was treated with NaH (60%, 8.0 g, 0.2 mol) with the temperature maintained below 40 C. The reaction mixture was then stirred at 35 C. for 1 hour. N-(3-bromopropyl)-phthalimide (53.6 g, 0.2 mol) was added and the reaction mixture was stirred for 48 hours at 40 C. The reaction mixture was concentrated in vacuo to a gum and crystallized from EtOAC to give the title compound 33 g (54%) (mp 134-135 C.). 1 H NMR (DMSO) delta 2.21 (m, 2H, CH2), 3.61 (m, 2H, CH2), 4.30 (m, 2H, CH2), 7.88 (m, 4H, ArH), 8.36 (s, 1H, ArH).
The synthetic route of 1122-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Isis Pharmaceuticals, Inc.; US6107482; (2000); A;,
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