In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10111-08-7, name is Imidazole-2-carboxaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: Imidazole-2-carboxaldehyde
General Procedure E; (according literature reference Bioorg. Med. Chem. 2005, 13 , 363-386) [00126] l-ethyl-lH-imidazole-2-carbaldehyde[00127] To a heterogeneous mixture of imidazole-2-carboxaldehyde (500 mg, 5.20 mmol, 1 eq) and potassium carbonate (863 mg, 6.24 mmol, 1.2 eq) in N,N-dimethylformamide (5.0 mL) was added iodoethane (0.499 mL, 6.24 mmol, 1.2 eq). The reaction mixture was heated to 50 0C for 5 hours then cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was separated and washed successively with water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give crude l-ethyl-lH-imidazole-2-carbaldehyde as a mixture with N,N- dimethylformamide (-1: 1) which was used without further purification. [00128]
The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2009/67233; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem