In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17289-20-2 as follows. Computed Properties of C6H8N2O2
EXAMPLE 8 Preparation of 1-methyl-5-hydroxymethylimidazole To a suspension of 1.4 g (0.01 mol) of 1-methyl-5-carbmethoxyimidazole in 5 ml of water is added 0.8 g (0.02 mol) of sodium hydroxide, and the mixture was heated to reflux for 2 hours. To the mixture is added 4 ml of ~37percent aqueous formaldehyde solution, and the resultant mixture is heated at 80-90 for 2 hours. After completion of the reaction, the solvent is stripped off and the residue is extracted with ethyl acetate. The ethyl acetate extract was concentrated to give 1-methyl-5-hydroxymethylimidazole as a solid, m.p. 112¡ã-114¡ã C.
According to the analysis of related databases, 17289-20-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Korea Institute of Science and Technology; US4292431; (1981); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem