Adding a certain compound to certain chemical reactions, such as: 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7757-21-3, Computed Properties of C8H10ClN3
In a 100 mL three-necked flask, NaOH (15 g, 0.38 mol) and 15 mL of water were added, mechanically stirred, and after clearing, III-1 (2.63 g, 14.32 mmol) was added.Tetrabutylammonium bromide (185 mg, 0.57 mmol) was stirred at 25 C for 1 hour, and a solution of 1,2-dibromoethane (5.38 g, 28.64 mmol) dissolved in 50 mL of DMF was added dropwise.After the completion of the dropwise addition, the reaction was carried out at 25 C for 4 hours, and filtered by suction.Inorganic salt, concentrated under reduced pressure to give a white solid.Column chromatography (dichloromethane:methanol:aqueous ammonia = 50:1: 0.05 to 40:1:0.05) was purified to afford product (IV-1) 1.25 g, yield 50.4%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Xu Yungen; Wang Junwei; Li Hui; Zhang Guangxia; Ge Yiran; Guan Zhe; (15 pag.)CN109251204; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem