Application of 104619-51-4,Some common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, molecular formula is C7H7N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2S: r4-(5-Amno- M .3.41 oxadiazol-2-vO-pyridin-3-ylH2-fluoro-4-methoxy- phenvD-amine; To a solution of 3-(2-Fluoro-4-methoxy-phenylamino)-isonicotinic acid hydrazide (150mg, 0.54mmol, 1eq) in DMSO (2ml_) C- (Di-imidazol-i-yl)-methyleneamine (175mg, 1.09mmol, 2eq) was added. The reaction mixture was stirred at RT under argon overnight and then poured into water. The product was isolated by filtration (89 mg). LC/MS (Method A) [0.52mi?; 302(M+1)]
The synthetic route of 104619-51-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/123936; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem