Synthetic Route of 641571-11-1,Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 12; Preparation of NilotinibTo 1 L glass reactor was added the compound of formula 4-methyl-3-{[4-(pyridin-3-yl) pyrimidin-2-yl]amino}benzoic acid of formula X (80.0 g, 0.26 mol), and N-Methyl-pyrrolidone (400 mL). The mixture was heated to 60 C., then SOCl2 (24 mL, 0.33 mol) was added during 15 minutes. The resulted mixture was stirred at 60 C. for 1 h. A compound of formula I (69.2 g, 0.29 mol) was added and the reaction mixture was stirred and heated to 90 C. for 3 h. Water (500 mL) was added and the solution was heated to 80 C. NaOH 47% solution (65 mL) was added until pH 11-12. Then, the suspension was cooled to 40 C. and stirred at this temperature for 2 hours, filtered under reduced pressure at 40 C., and washed with 500 mL H2O to yield a beige solid. This material was slurried in water (1 L) at 40 C. for 1 h, filtered, washed with water (500 mL), and dried under vacuum at 50 C. to obtain 135.25 g of Nilotinib base with 94% yield. (95.8% assay, 99.46% purity).
The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; US2010/16590; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem