68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-Methyl-1H-imidazole-4-carbaldehyde
43[0095] To a solution of O-adamantylhydroxylamine (0.17g, lmmol) and 4-methyl-lH- imidazole-5-carbaldehyde (0.1 Ig, lmmol) in 5ml anhydrous DMSO was added 3mul CH3COOH. The resulting mixture was stirred at ambient temperature overnight. H2O (40ml) was added and the mixture was lyophilized to give white solid. (0.25g, Yield: 96%). 1H-NMR (360 MHz, CDCl3) delta 8.08 (s, IH), 7.55 (s, IH), 2.31 (s, 3H), 2.18 (br s, 3H), 1.88 (br s, 6H), 1.63 (br s, 6H); 13C-NMR (90 MHz, CDCl3) delta 138.5, 138.3, 135.22, 78.16, 41.79, 36.65, 30.84, 12.10; ESI-MS: Calculated for C15H2iN3O (M + H)+ 260.4, Found: 260.2.
The synthetic route of 68282-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; DeGRADO, William, F.; WANG, Jun; WO2011/22191; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem