Related Products of 53484-18-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of CDI (1.2 equiv) and the proper carboxylic acid in anhydrous solvent under a N2 atmosphere, was stirred at 40-50 C for 3 h. The solution was then cooled at room temperature and 2-amino-5-nitrothiazole and in some cases 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was added. The mixture was heated at 60 C for 12-18 h, cooled at room temperature and water was added to precipitate the hybrid compounds. The solid was filtered and washed with acetone and water for give the corresponding hybrid compounds.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Soria-Arteche, Olivia; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Trejo-Soto, Pedro Josue; Hernandez-Luis, Francisco; Gres-Molina, Jorge; Maldonado, Luis A.; Castillo, Rafael; Bioorganic and Medicinal Chemistry Letters; vol. 23; 24; (2013); p. 6838 – 6841;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem