Electric Literature of 16681-59-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
a) Synthesis of 1-(1-methyl-1H-imidazol-2-yl)piperazine 1.0 g (6.2 mmol) 2-bromine-1-methyl-1H-imidazol was fused with 3.2 ml (37.0 mmol) piperazine at 145 C. and stirred for 18 h at this temperature. After cooling to RT, the residue was received in 10% aq. hydrochloric acid and washed with AE. Alkalic adjustment was subsequently performed with a 10% aq. NaOH sol. (pH>12) and extraction with DCM. The organic phase was dried over MgSO4, filtered and concentrated in a vacuum. In this process, 780 mg (4.7 mmol, 76%) 1-(1-methyl-1H-imidazol-2-yl)piperazine was obtained.
The synthetic route of 2-Bromo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Grunenthal GmbH; US2008/261996; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem